The zone of coagulation in a burn injury represents the area of maximum damage where tissue necrosis is immediate and irreversible. This zone is characterized by protein coagulation and cell death due to intense heat exposure. Unlike the surrounding zones, this area cannot recover, as the vascular structures and cellular architecture are destroyed beyond repair. Recognizing this zone is crucial for surgical planning, as debridement of necrotic tissue from the zone of coagulation is necessary to prevent infection and promote wound healing. Preservation efforts should focus on the adjacent zones, which may still be viable.

Reference: "Sabiston Textbook of Surgery," Townsend CM Jr et al., 21st Edition.