Wound dehiscence is the most common complication of untreated surgical site infections because the infection weakens the integrity of the surgical wound by causing tissue necrosis and inflammation. This disruption prevents proper collagen formation and wound healing, leading to partial or complete separation of the wound edges. Prompt management of infection is crucial to maintain wound strength and prevent dehiscence. While sepsis, cellulitis, and abscess can occur, wound dehiscence directly results from the local failure of the wound to heal in an infected environment.

Reference: Sabiston Textbook of Surgery, Townsend et al., 21st Edition.