Which ethical principle mandates that the anticipated benefits of a clinical study must surpass the potential harm to its participants?

- The principle of Beneficence requires that researchers maximize potential benefits while minimizing possible harms to participants.
- It mandates a careful risk-benefit analysis ensuring that the anticipated benefits outweigh the potential risks.
- This ethical guideline protects participants by promoting their well-being and justifies the conduct of clinical studies only when positive outcomes are expected.

Reference: Beauchamp & Childress, *Principles of Biomedical Ethics*, 8th Edition, Chapter 2, p. 94-95