Ectodermal dysplasia is a genetic disorder affecting the development of ectodermal tissues like skin, hair, nails, and teeth, but it does not directly cause malocclusion. Malocclusion typically arises from mechanical or developmental factors such as supernumerary teeth causing crowding, thumb sucking leading to anterior open bite, or premature loss of teeth resulting in space loss and misalignment. Since ectodermal dysplasia primarily affects tooth number and form rather than alignment or occlusion, it is not considered a direct etiology of malocclusion.

Reference: Neville et al., Oral & Maxillofacial Pathology, 4th Edition.