Articaine has the fastest onset of action among local anesthetics due to its unique chemical structure containing a thiophene ring, which enhances lipid solubility and allows it to penetrate nerve membranes more efficiently. This results in quicker diffusion to the site of action compared to other agents like lidocaine or bupivacaine. Clinically, this makes articaine highly effective for rapid anesthesia in dental and minor surgical procedures. Its rapid onset improves patient comfort and reduces waiting time during local infiltration.

Reference: Clinical Anesthesia, Barash, Cullen, Stoelting, 8th Edition.