Boyle's Law states that at a constant temperature, the pressure of a gas is inversely proportional to its volume. In clinical practice, this principle is essential for understanding lung mechanics during ventilation. When lung volume decreases, intrapulmonary pressure increases, allowing air to flow out; conversely, increasing lung volume lowers pressure, facilitating air inflow. This relationship is crucial for understanding breathing physiology and mechanical ventilation in surgical patients. Accurate application of Boyle’s Law helps optimize ventilation strategies and prevent barotrauma or volutrauma during anesthesia.

Reference: Guyton and Hall Textbook of Medical Physiology, Guyton & Hall, 13th Edition.