Which antithyroid drug is associated with fetal aplasia cutis and choanal atresia?

A Methimazole

B Propylthiouracil

C Carbimazole

D Levothyroxine

Solution

Correct Answer: Option B

The correct answer is Propylthiouracil (PTU) is not typically associated with fetal aplasia cutis or choanal atresia. These congenital anomalies are primarily linked to Methimazole and Carbimazole, which are known teratogens causing these defects when used during pregnancy. PTU is preferred in the first trimester of pregnancy due to its lower teratogenic risk. Therefore, the association of fetal aplasia cutis and choanal atresia with PTU is incorrect; these defects are related to methimazole/carbimazole use.

Reference: Harrison's Principles of Internal Medicine, Jameson et al., 20th Edition.

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