Glycopyrrolate is an anticholinergic agent commonly used during general anesthesia to reduce salivary, respiratory, and gastric secretions. This action helps to maintain a clear surgical field and reduces the risk of aspiration and airway complications. Unlike atropine, glycopyrrolate has minimal central nervous system effects due to poor blood-brain barrier penetration. Its use is particularly important during intubation and surgeries involving the airway or upper gastrointestinal tract. The reduction of secretions improves airway management and decreases perioperative respiratory complications, making it a vital adjunct in anesthetic practice.

Reference: Miller's Anesthesia, Ronald D. Miller, 9th Edition.