Which immunohistochemical protein marker is characteristically expressed by Schwann cells?
সমাধান
সঠিক উত্তর: Option D
English Explanation
S-100 protein is an acidic calcium-binding protein that is characteristically expressed by cells derived from the neural crest, including Schwann cells, melanocytes, glial cells, and chondrocytes [1-3]. In histopathology, S-100 is highly sensitive for tumors of Schwann cell origin, such as Schwannoma (neurilemmoma) and Neurofibroma, making S-100 protein the correct answer .
Why other options are incorrect:
- Desmin: It is an intermediate filament marker specific for muscle cells (skeletal, cardiac, and smooth muscle) and myogenic tumors like Leiomyoma and Rhabdomyosarcoma .
- Vimentin: It is an intermediate filament characteristically expressed by mesenchymal cells and sarcomas .
- Cytokeratin: It is an intermediate filament marker characteristically expressed by epithelial cells and is used to identify carcinomas .
বাংলা ব্যাখ্যা
S-100 protein একটি acidic calcium-binding protein যা মূলত neural crest-derived cells যেমন— Schwann cells, melanocytes, glial cells, এবং chondrocytes-এ পাওয়া যায় [1-3]. Schwannoma এবং Neurofibroma-র মতো peripheral nerve sheath tumors সনাক্তকরণে S-100 অত্যন্ত সংবেদনশীল (highly sensitive) immunohistochemical marker হিসেবে ব্যবহৃত হয় .
অন্যান্য অপশনগুলো ভুল হওয়ার কারণ:
- Desmin: এটি muscle cells (skeletal, smooth, এবং cardiac muscle) এর একটি intermediate filament marker যা myogenic origin-এর টিউমার সনাক্তকরণে ব্যবহৃত হয় .
- Vimentin: এটি mesenchymal cells এবং sarcomas সনাক্তকরণের জন্য ব্যবহৃত একটি সাধারণ marker .
- Cytokeratin: এটি epithelial cells এবং epithelium-derived tumors যেমন— carcinoma সনাক্তকরণে ব্যবহৃত হয় .
BCS High Yield Points
- S-100 protein is the diagnostic marker of choice for Schwannoma, Neurofibroma, and Melanoma .
- Cytokeratin is the hallmark intermediate filament for epithelial tumors (Carcinomas) .
- Desmin is highly specific for tumors of myogenic origin (muscle origin tumors) .
- Vimentin is a common marker used to distinguish cells of mesenchymal origin from epithelial cells .
Source: Textbook of Pathology
S-100 protein is an acidic calcium-binding protein that is characteristically expressed by cells derived from the neural crest, including Schwann cells, melanocytes, glial cells, and chondrocytes [1-3]. In histopathology, S-100 is highly sensitive for tumors of Schwann cell origin, such as Schwannoma (neurilemmoma) and Neurofibroma, making S-100 protein the correct answer .
Why other options are incorrect:
- Desmin: It is an intermediate filament marker specific for muscle cells (skeletal, cardiac, and smooth muscle) and myogenic tumors like Leiomyoma and Rhabdomyosarcoma .
- Vimentin: It is an intermediate filament characteristically expressed by mesenchymal cells and sarcomas .
- Cytokeratin: It is an intermediate filament marker characteristically expressed by epithelial cells and is used to identify carcinomas .
বাংলা ব্যাখ্যা
S-100 protein একটি acidic calcium-binding protein যা মূলত neural crest-derived cells যেমন— Schwann cells, melanocytes, glial cells, এবং chondrocytes-এ পাওয়া যায় [1-3]. Schwannoma এবং Neurofibroma-র মতো peripheral nerve sheath tumors সনাক্তকরণে S-100 অত্যন্ত সংবেদনশীল (highly sensitive) immunohistochemical marker হিসেবে ব্যবহৃত হয় .
অন্যান্য অপশনগুলো ভুল হওয়ার কারণ:
- Desmin: এটি muscle cells (skeletal, smooth, এবং cardiac muscle) এর একটি intermediate filament marker যা myogenic origin-এর টিউমার সনাক্তকরণে ব্যবহৃত হয় .
- Vimentin: এটি mesenchymal cells এবং sarcomas সনাক্তকরণের জন্য ব্যবহৃত একটি সাধারণ marker .
- Cytokeratin: এটি epithelial cells এবং epithelium-derived tumors যেমন— carcinoma সনাক্তকরণে ব্যবহৃত হয় .
BCS High Yield Points
- S-100 protein is the diagnostic marker of choice for Schwannoma, Neurofibroma, and Melanoma .
- Cytokeratin is the hallmark intermediate filament for epithelial tumors (Carcinomas) .
- Desmin is highly specific for tumors of myogenic origin (muscle origin tumors) .
- Vimentin is a common marker used to distinguish cells of mesenchymal origin from epithelial cells .
Source: Textbook of Pathology
